Data di Pubblicazione:
2016
Citazione:
Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes / Delitala, Alessandro P.; Pes, Giovanni Mario; Malaty, Hoda M.; Pisanu, Gavino; Delitala, Giuseppe; Dore, Maria Pina. - In: JOURNAL OF DIABETES RESEARCH. - ISSN 2314-6745. - (2016), pp. 1-6. [10.1155/2016/7347065]
Abstract:
Background. Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results
are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults
(LADA). In this study, a correlation among H. pylori infection and the risk of autoimmune diabetes in comparison with T2D was
investigated. Methods. Sera from 234 LADA patients, 105 patients with late-onset T1D, and 156 patients with T2D were analyzed
for anti-H. pylori and the cytotoxin-associated antigen (CagA) IgG antibodies. Results. H. pylori seroprevalence was comparable in
LADA (52%), late-onset T1D (45%), and T2D (49%) with no gender differences.The seroprevalence of CagA IgG was significantly
higher in autoimmune diabetes (late-onset T1D: 45%, LADA: 40%) compared to T2D (25%; < 0.028). Conclusions. Although H.
pylori seroprevalence was similar in LADA, T1D, and T2D, anti-CagA positivity was significantly increased among patients with
autoimmune diabetes, suggesting that more virulent H. pylori strains might be a trigger for immune mechanisms involved in their
pathogenesis.
are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults
(LADA). In this study, a correlation among H. pylori infection and the risk of autoimmune diabetes in comparison with T2D was
investigated. Methods. Sera from 234 LADA patients, 105 patients with late-onset T1D, and 156 patients with T2D were analyzed
for anti-H. pylori and the cytotoxin-associated antigen (CagA) IgG antibodies. Results. H. pylori seroprevalence was comparable in
LADA (52%), late-onset T1D (45%), and T2D (49%) with no gender differences.The seroprevalence of CagA IgG was significantly
higher in autoimmune diabetes (late-onset T1D: 45%, LADA: 40%) compared to T2D (25%; < 0.028). Conclusions. Although H.
pylori seroprevalence was similar in LADA, T1D, and T2D, anti-CagA positivity was significantly increased among patients with
autoimmune diabetes, suggesting that more virulent H. pylori strains might be a trigger for immune mechanisms involved in their
pathogenesis.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Delitala, Alessandro P.; Pes, Giovanni Mario; Malaty, Hoda M.; Pisanu, Gavino; Delitala, Giuseppe; Dore, Maria Pina
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