MAC-sparing effect of nitrous oxide in sevoflurane anesthetized sheep and its reversal with systemic atipamezole administration
Articolo
Data di Pubblicazione:
2018
Citazione:
MAC-sparing effect of nitrous oxide in sevoflurane anesthetized sheep and its reversal with systemic atipamezole administration / Duffee, Lauren; Columbano, Nicolò; Scanu, Antonio; Melosu, Valentino; Careddu, Giovanni Mario; Sotgiu, Giovanni; Driessen, Bernd. - In: PLOS ONE. - ISSN 1932-6203. - 13:1(2018), p. e0190167. [10.1371/journal.pone.0190167]
Abstract:
Nitrous oxide (N2O) is an anesthetic gas with antinociceptive properties and reduces the minimum alveolar concentration (MAC) for volatile anesthetic agents, potentially through mechanisms involving central alpha2-adrenoceptors. We hypothesized that 70% N2O in the inspired gas will significantly reduce the MAC of sevoflurane (MACSEVO) in sheep, and that this effect can be reversed by systemic atipamezole.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Duffee, Lauren; Columbano, Nicolò; Scanu, Antonio; Melosu, Valentino; Careddu, Giovanni Mario; Sotgiu, Giovanni; Driessen, Bernd
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