Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
Articolo
Data di Pubblicazione:
2017
Citazione:
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis / Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Migliori, Giovanni Battista. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6040. - 23:10(2017). [10.3201/eid2310.170834]
Abstract:
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Europe; India; Italy; MDR TB; Mycobacterium tuberculosis; Russia; Switzerland; TB; United Kingdom; XDR TB; antimicrobial resistance; bacteria; bedaquiline; combination treatment; delamanid; effectiveness; multidrug resistance; multidrug-resistant tuberculosis; mycobacteria; pulmonary; respiratory infections; safety; the Netherlands; tolerability; tuberculosis
Elenco autori:
Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Migliori, Giovanni Battista
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