Investigation of the effects of Lycium Barbarum Polysaccharides against cadmium induced damage in testis
Articolo
Data di Pubblicazione:
2017
Citazione:
Investigation of the effects of Lycium Barbarum Polysaccharides against cadmium induced damage in testis / Varoni, M.V., Gadau, S.D., Pasciu, V., Baralla, E., Serra, E., Palomba, D., Demontis, M.P.. - In: EXPERIMENTAL AND MOLECULAR PATHOLOGY. - ISSN 0014-4800. - 103:(2017), pp. 26-32. [10.1016/j.yexmp.2017.06.003]
Abstract:
This study describes the effects of Lycium barbarum polysaccharides (LBP) on testicular damage induced by
cadmium (Cd). Adult male rats were i.p. injected with CdCl2 (4 mg/Kg, once) with or without LBP pretreatment
(300 mg/Kg orally, once a day, for 30 days). Testis weight, morphological/histological structure and oxidative
stress parameters were evaluated. Several adverse effects were observed after CdCl2 injection, with a significant
decrease in body/testis weight ratio (P < 0.05), gross morphological changes with hyperemia of the parenchyma,
increased volume and alteration in the structure of the seminiferous tubules. Furthermore, Cd intoxication
caused a significant decrease of glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC)
in testis (P < 0.05) together with a significant increase (P < 0.01) of 3-nitro-L-tyrosine (3NT) while malondialdehyde
(MDA) did not change. LBP pretreatment caused slight signs of improvement in the morphology of
the seminiferous tubules. Our results confirm that Cd induces testicular damage and suggest the oxidative stress
involvement. LBP could ameliorate Cd testicular damage but further investigations are needed.
cadmium (Cd). Adult male rats were i.p. injected with CdCl2 (4 mg/Kg, once) with or without LBP pretreatment
(300 mg/Kg orally, once a day, for 30 days). Testis weight, morphological/histological structure and oxidative
stress parameters were evaluated. Several adverse effects were observed after CdCl2 injection, with a significant
decrease in body/testis weight ratio (P < 0.05), gross morphological changes with hyperemia of the parenchyma,
increased volume and alteration in the structure of the seminiferous tubules. Furthermore, Cd intoxication
caused a significant decrease of glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC)
in testis (P < 0.05) together with a significant increase (P < 0.01) of 3-nitro-L-tyrosine (3NT) while malondialdehyde
(MDA) did not change. LBP pretreatment caused slight signs of improvement in the morphology of
the seminiferous tubules. Our results confirm that Cd induces testicular damage and suggest the oxidative stress
involvement. LBP could ameliorate Cd testicular damage but further investigations are needed.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
cadmium, testis, Lycium barbarum polysaccharide, oxidative stress, 3-nitro-L-tyrosine
Elenco autori:
Varoni, Maria Vittoria; Gadau, Sergio Domenico; Pasciu, Valeria; Baralla, Elena; Serra, Elisa; Palomba, Domenico; Demontis, Maria Piera
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