Data di Pubblicazione:
2016
Citazione:
Benzoxaborole as a new chemotype for carbonic anhydrase inhibition / Alterio, Vincenzo; Cadoni, Roberta; Esposito, Davide; Vullo, Daniela; Fiore, Anna Di; Monti, Simona Maria; Caporale, Andrea; Ruvo, Menotti; Sechi, Mario; Dumy, Pascal; Supuran, Claudiu T.; Simone, Giuseppina De; Winum, Jean Yves. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 52:80(2016), pp. 11983-11986. [10.1039/c6cc06399c]
Abstract:
In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Catalysis; Electronic, Optical and Magnetic Materials; Ceramics and Composites; Chemistry (all); Surfaces, Coatings and Films; 2506; Materials Chemistry2506 Metals and Alloys
Elenco autori:
Alterio, Vincenzo; Cadoni, Roberta; Esposito, Davide; Vullo, Daniela; Fiore, Anna Di; Monti, Simona Maria; Caporale, Andrea; Ruvo, Menotti; Sechi, Mario; Dumy, Pascal; Supuran, Claudiu T.; Simone, Giuseppina De; Winum, Jean Yves
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