Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as potential anticancer agent of the Auoxo3-loaded protein.
Articolo
Data di Pubblicazione:
2016
Citazione:
Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as potential anticancer agent of the Auoxo3-loaded protein / Ferraro, Giarita; Monti, Daria Maria; Amoresano, Angela; Pontillo, Nicola; Petruk, Ganna; Pane, Francesca; Cinellu, Maria Agostina; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 52:(2016), pp. 9518-9521. [10.1039/c6cc02516a]
Abstract:
Auoxo3, a cytotoxic gold(III) compound, was encapsulated within a
ferritin nanocage. Inductively coupled plasma mass spectrometry,
circular dichroism, UV-Vis absorption spectroscopy and X-ray
crystallography confirm the potential-drug encapsulation. The
structure shows that naked Au(I) ions bind to the side chains of
Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147.
The gold-encapsulated nanocarrier has a cytotoxic effect on different
aggressive human cancer cells, whereas it is significantly less cytotoxic
for non-tumorigenic cells.
ferritin nanocage. Inductively coupled plasma mass spectrometry,
circular dichroism, UV-Vis absorption spectroscopy and X-ray
crystallography confirm the potential-drug encapsulation. The
structure shows that naked Au(I) ions bind to the side chains of
Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147.
The gold-encapsulated nanocarrier has a cytotoxic effect on different
aggressive human cancer cells, whereas it is significantly less cytotoxic
for non-tumorigenic cells.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
GOLD COMPLEXES, CYTOTOXICITY, FERRITINE NANOCAGE, ENCAPSULATION
Elenco autori:
Ferraro, Giarita; Monti, Daria Maria; Amoresano, Angela; Pontillo, Nicola; Petruk, Ganna; Pane, Francesca; Cinellu, Maria Agostina; Merlino, Antonello
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