Data di Pubblicazione:
2005
Citazione:
Mechanisms of cytotoxycity of selected organogold(III) compounds / Coronnello, M; Mini, E; Caciagli, B; Cinellu, Maria Agostina; Bindoli, A; Gabbiani, C; Messori, L.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:(2005), pp. 6761-6765. [10.1021/jm050493o]
Abstract:
The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells
were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced
significant antiproliferative effects and promoted apoptosis to a greater extent than platinum
drugs while causing only modest cell cycle modifications. The mechanistic implications of these
findings are discussed: mitochondrial pathways are proposed to be directly involved in the
apoptotic process in relation to selective inhibition of thioredoxin reductase.
were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced
significant antiproliferative effects and promoted apoptosis to a greater extent than platinum
drugs while causing only modest cell cycle modifications. The mechanistic implications of these
findings are discussed: mitochondrial pathways are proposed to be directly involved in the
apoptotic process in relation to selective inhibition of thioredoxin reductase.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
organogold; antitumor activity; DNA
Elenco autori:
Coronnello, M; Mini, E; Caciagli, B; Cinellu, Maria Agostina; Bindoli, A; Gabbiani, C; Messori, L.
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