Data di Pubblicazione:
2015
Citazione:
Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study / Wesnes, K; Riise, T; Casetta, I; Drulovic, J; Granieri, Enrico; Holmøy, T; Kampman, Mt; Landtblom, Am; Lauer, K; Lossius, A; Magalhaes, S; Pekmezovic, T; Bjørnevik, K; Wolfson, C; Pugliatti, Maura; Myhr, Km. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 20:(2015), pp. 458-467. [10.1177/1352458514546785]
Abstract:
BACKGROUND:
Obesity may be a risk factor for developing multiple sclerosis (MS).
OBJECTIVE:
We examined if body size influences the risk of MS in a population-based, case control study.
METHODS:
A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.
RESULTS:
In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.
CONCLUSIONS:
Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.
Obesity may be a risk factor for developing multiple sclerosis (MS).
OBJECTIVE:
We examined if body size influences the risk of MS in a population-based, case control study.
METHODS:
A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.
RESULTS:
In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.
CONCLUSIONS:
Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
multiple sclerosis; body mass index; epidemiology; case control study
Elenco autori:
Wesnes, K; Riise, T; Casetta, I; Drulovic, J; Granieri, Enrico; Holmøy, T; Kampman, Mt; Landtblom, Am; Lauer, K; Lossius, A; Magalhaes, S; Pekmezovic, T; Bjørnevik, K; Wolfson, C; Pugliatti, Maura; Myhr, Km
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