Soluble Epoxide Hydrolase Inhibitors: New Molecules with Potential for Use in Veterinary Medicine

Treatments for inflammation and pain are important consideration in human and veterinary medicine. The
classical drugs for treatments of inflammation and pain act by inhibition of cyclooxygenase and lypoxygenase
pathways. However, there is still a need to develop new veterinary drugs and trials to apply human drugs
to the veterinary field in order to increase the veterinary drug armamentarium. However, it is pivotal to
experimentally test human drugs and therapies in veterinary species before veterinary clinical applications.
The soluble epoxide hydrolase inhibitors (sEHIs), are novel active ingredients shown to have a number of
beneficial effects. This has been especially demonstrated in many animal models in relation to inflammation
and pain. The present review reports the state of the art of soluble epoxide hydrolase inhibitors and suggests
their potential use in veterinary medicine.