Association of trace elements with lipid profiles and glycaemic control in patients with type 1 diabetes mellitus in northern Sardinia, Italy: An observational study
Articolo
Data di Pubblicazione:
2015
Citazione:
Association of trace elements with lipid profiles and glycaemic control
in patients with type 1 diabetes mellitus in northern Sardinia, Italy:
An observational study / Peruzzu, A; Solinas, Maria Giuliana; Asara, Y; Forte, G; Bocca, B; Tolu, F; Malaguarnera, L; Montella, Andrea Costantino Mario; Madeddu, Roberto Beniamino. - In: CHEMOSPHERE. - ISSN 0045-6535. - 132:(2015), pp. 101-107. [10.1016/j.chemosphere.2015.02.052]
Abstract:
Sardinia is an Italian region with a high incidence of type 1 diabetes mellitus. This study aimed to determine
the associations of trace elements with lipid profiles and glycaemic control in patients with T1DM.
A total of 192 patients with T1DM who attended the Unit of Diabetology and Metabolic Diseases in
Sassari, Italy, were enrolled. Trace elements zinc, copper, selenium, chromium, and iron were measured
in whole blood by sector field inductively coupled plasma mass spectrometry. The correlations between
metabolic variables and the levels of trace elements were determined. Zinc was positively correlated with
total cholesterol (P = 0.023), low-density lipoprotein (P = 0.0015), and triglycerides (P = 0.027). Iron as
significantly correlated with TC (P = 0.0189), LDL (P = 0.0121), and high-density lipoprotein (HDL)
(P = 0.0466). In males, Cr was positively correlated with HDL (P = 0.0079) and Se, in females was
correlated with TG (P = 0.0113). The mean fasting plasma glucose was166.2 mg dL1. Chromium was
correlated with fasting plasma glucose (P = 0.0149), particularly in males (P = 0.0038). Overall, 63.5% of
the patients had moderate HbA1c (7–9%). Copper was significantly correlated with HbA1c% in males
(P = 0.0155). In conclusion, the results of this study indicate that trace elements show different associations
with lipid levels and glycaemic control in T1DM. Zinc, Fe, and Se were associated with lipid levels
whereas Cu and Cr were associated with HbA1c%.
the associations of trace elements with lipid profiles and glycaemic control in patients with T1DM.
A total of 192 patients with T1DM who attended the Unit of Diabetology and Metabolic Diseases in
Sassari, Italy, were enrolled. Trace elements zinc, copper, selenium, chromium, and iron were measured
in whole blood by sector field inductively coupled plasma mass spectrometry. The correlations between
metabolic variables and the levels of trace elements were determined. Zinc was positively correlated with
total cholesterol (P = 0.023), low-density lipoprotein (P = 0.0015), and triglycerides (P = 0.027). Iron as
significantly correlated with TC (P = 0.0189), LDL (P = 0.0121), and high-density lipoprotein (HDL)
(P = 0.0466). In males, Cr was positively correlated with HDL (P = 0.0079) and Se, in females was
correlated with TG (P = 0.0113). The mean fasting plasma glucose was166.2 mg dL1. Chromium was
correlated with fasting plasma glucose (P = 0.0149), particularly in males (P = 0.0038). Overall, 63.5% of
the patients had moderate HbA1c (7–9%). Copper was significantly correlated with HbA1c% in males
(P = 0.0155). In conclusion, the results of this study indicate that trace elements show different associations
with lipid levels and glycaemic control in T1DM. Zinc, Fe, and Se were associated with lipid levels
whereas Cu and Cr were associated with HbA1c%.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Peruzzu, A; Solinas, Maria Giuliana; Asara, Y; Forte, G; Bocca, B; Tolu, F; Malaguarnera, L; Montella, Andrea Costantino Mario; Madeddu, Roberto Beniamino
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