Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore

Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore / Pala, Nicolino; Ladu, Federico; Szlasa, Wojciech; Cadoni, Roberta; Lomelino, Carrie; Mahon, Brian P.; Gulkis, Mitchell; Mckenna, Robert; Dessì, Alessandro; Dallocchio, Roberto; Demelas, Antonio; Carcelli, Mauro; Rogolino, Dominga; Crosio, Claudia; Iaccarino, Ciro; Kulbacka, Julita; Vullo, Daniela; Carta, Fabrizio; Supuran, Claudiu T.; Sechi, Mario. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 298:(2025). [10.1016/j.ejmech.2025.118043]