Sonographic findings before and after maternal administration of hyperimmune globulin in women with fetal cytomegalovirus infection

10–14
October
2010,
Prague,
Czech
Republic
Oral
communication
abstracts
Sonographic
findings
before
and
after
maternal
administration
of
hyperimmune
globulin
in
women
with
fetal
cytomegalovirus
infection
N.
Gussetti1,
S.
Visentin2,
R.
Manara3,
MD
Piga
4,V.
Citton1,
E.
Salviato2,
E.
Cosmi2
1Infectious
Disease,
University
of
Padua,
Padua,
Italy;
2Obstetrics
and
Gynecology,
University
of
Padua,
Padua,
Italy;
3Neuroradiology,
University
of
Padua,
Padua,
Italy
4
Obstetrics
and
Gynecology,
University
of
Sassari,
Sassari,
Italy
Objectives:
To
assess
ultrasound
findings
in
pregnant
women
with
fetal
CMV
infection
treated
with
hyperimmune
serum
anti-­‐CMV
(CMV-­‐Ig).
Methods:
Between
January
2002
and
December
2009,
501
women
with
primary
CMV
infection
were
identified.
Among
them,
47
women
had
a
CMV-­‐positive
amniotic
fluid
(AF)
sampled
after
20
weeks
of
gestation
and
at
least
6–8
weeks
after
primary
infection.
Twenty-­‐three
women
received
200
UI/kg
of
CMV-­‐Ig
by
single
endovenous
infusion
between
23
and
29
weeks
of
gestation,
24
did
not
received
CMV-­‐Ig.
Fetal
ultrasonography
was
performed
monthly.
Follow
up
in
infants
was
performed
at
a
median
age
of
14
months
(range
6–24).
Results:
In18/47
fetuses
CMV-­‐associated
ultrasound
abnormalities
(IUGR,
bowel/hepatic
hyperechogenicity,
cerebral
periventricular
with
non-­‐obese
women.
This
information
will
be
useful
for
genetic
counseling
prior
to
prenatal
invasive
procedures.
OC20.04:
Table
1.
Maternal
obesity
and
fetal
loss
rates
from
invasive
procedures
Obese:
n
(%)
Non-­‐obese:
n
(%)
Adjusted
OR
(95%
CI
)
P-­‐value
CVS
50/780
(6.4)
257/3941
(6.5)
1.0
(0.7–1.3)
0.91
Amniocentesis
108/2265
(4.8)
301/7700
(3.9)
1.7
(1.2–2.1)
<0.01
Ultrasound
in
Obstetrics
&
Gynecology
2010;
36
(Suppl.
1):
1–51
37