Data di Pubblicazione:
2007
Citazione:
HPLC-DAD determination of mepivacaina in cerebrospinal fluid from a fatal case / Nieddu, M.; Boatto, Gianpiero; Serra, D.; Soro, A.; Lorenzoni, S.; Lubinu, F.. - In: JOURNAL OF FORENSIC SCIENCES. - ISSN 0022-1198. - 52 (5):5(2007), pp. 1223-1224. [10.1111/j.1556-4029.2007.00526.x]
Abstract:
A fatal case involving mepivacaine-induced epidural anesthesia is described. The pathological findings were typical of cardiac
shock from ischemic origin. Cerebrospinal fluid (CSF) was obtained several hours after death and mepivacaine was identified by gas chromatography-
mass spectrometry (GC-MS). Its concentration was determined by high performance liquid chromatography with diode array detection
(HPLC–DAD). Extraction from CSF was performed by deproteinization with acetonitrile. The mepivacaine concentration in the sample was
264 lg ⁄ mL. Concentrations of mepivacaine in CSF following epidural anesthesia are not reported in literature to our knowledge. This is the first
reported case of death in which the mepivacaine concentration in CSF has been determined.
shock from ischemic origin. Cerebrospinal fluid (CSF) was obtained several hours after death and mepivacaine was identified by gas chromatography-
mass spectrometry (GC-MS). Its concentration was determined by high performance liquid chromatography with diode array detection
(HPLC–DAD). Extraction from CSF was performed by deproteinization with acetonitrile. The mepivacaine concentration in the sample was
264 lg ⁄ mL. Concentrations of mepivacaine in CSF following epidural anesthesia are not reported in literature to our knowledge. This is the first
reported case of death in which the mepivacaine concentration in CSF has been determined.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
forensic science; toxicology; mepivacaine hydrochloride; epidural anaesthesia; cerebrospinal fluid
Elenco autori:
Nieddu, M.; Boatto, Gianpiero; Serra, D.; Soro, A.; Lorenzoni, S.; Lubinu, F.
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