Sodium iodide associated to salicylic acid in the topical management of chronic oral candidiasis: a randomized trial

Abstract
Candidiasis is a relevant problem in oral medicine practice. We compared the ~;ntimyootic activity of nystatin with a solution
of sodium iodide associated to salicylic acid (SISA) in the topical management of chronìc candidiasis. Consecutive patients
affected by chronic candidiasis were randomly allocated to SISA (group A) or nystatin (group B). VAS and swab scores were
recorded at the beginning and at the end of the study while the healing index was evaluated at the end of the study only.
Data were analyzed by STATA 10 MP. Forty patients (20 male, 20 female) were randomized. SIAS was as effective as
nystatin in affecting VAS (p greater than 0.05) and swab score (p greater than 0.05). A statistically significant reduction (p
less than 0.05) ofhealing index was observed in both groups. No side effects were reported. SISA topical application, shows
a comparable efficacy to the nystatin in the management of chronic oral candidiasis. Its use could represent an adequate
alternative to the nystatin above ali in the cases of drug-resistance. Further large scale randomized trials are warranted to
confirrn these preliminary findings. .