[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains
Articolo
Data di Pubblicazione:
2007
Citazione:
[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains / Carta, A., Palomba, M.F.L., Paglietti, G., Molicotti, P., Paglietti, B., Cannas, S., Zanetti, S.A.L.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 17:(2007), pp. 4791-4794. [10.1016/j.bmcl.2007.06.064]
Abstract:
Abstract—In this preliminary study we report the activity of 3-methyl-9-substituted-6-oxo-6,9-dihydro-3H-[1,2,3]-triazolo
[4,5-h]quinolone-carboxylic acids and their esters as a new class of antiinfective agents against MDR Mycobacterium tuberculosis.
In antitubercular screening against H37Rv and 11 clinically isolated strains of M. tuberculosis several derivatives (1o,3a,c,i, j, p)
showed MIC 90 in the range 0.5–3.2lg/mL. 3c showed no cytotoxicity and proved to be the most potent derivative exhibiting
MIC 90=0.5lg/mL against all M. tuberculosis strains and infected human macrophages (J774-A1) tested.
[4,5-h]quinolone-carboxylic acids and their esters as a new class of antiinfective agents against MDR Mycobacterium tuberculosis.
In antitubercular screening against H37Rv and 11 clinically isolated strains of M. tuberculosis several derivatives (1o,3a,c,i, j, p)
showed MIC 90 in the range 0.5–3.2lg/mL. 3c showed no cytotoxicity and proved to be the most potent derivative exhibiting
MIC 90=0.5lg/mL against all M. tuberculosis strains and infected human macrophages (J774-A1) tested.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Triazolo[4,5-h]quinolones; MDR M. tuberculosis,; In vitro antitubercular activity.
Elenco autori:
Carta, Antonio; Palomba, Michele Francesco Luigi; Paglietti, G; Molicotti, Paola; Paglietti, B; Cannas, Sara; Zanetti, Stefania Anna Lucia
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