Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
Articolo
Data di Pubblicazione:
2022
Citazione:
Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD / Dinoto, A.; Sechi, E.; Ferrari, S.; Gajofatto, A.; Orlandi, R.; Solla, P.; Maccabeo, A.; Maniscalco, G. T.; Andreone, V.; Sartori, A.; Manganotti, P.; Rasia, S.; Capra, R.; Mancinelli, C. R.; Mariotto, S.. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 58:(2022), p. 103424. [10.1016/j.msard.2021.103424]
Abstract:
Post-vaccination disease relapses have been reported in patients with MOGAD and AQP4-IgG+NMOSD. In this retrospective multicenter Italian study we assessed the frequency of relapses after SARS-CoV-2 vaccination. We included 56 cases: MOGAD, 30; AQP4-IgG+NMOSD, 26. Vaccines received were BNT162b2-Pfizer-BioNTech in 42 patients and mRNA-1273-Moderna in 14 patients. Six patients had a history of SARS-CoV-2 infection; two of them experienced a post-infection disease relapse (MOGAD). The frequency of relapses within one month of SARS-CoV-2 vaccination was 4% (1/26) in the AQP4-IgG+NMOSD group and 0% in the MOGAD group. In these patients the potential benefits of vaccination overcome the risk of relapses.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
AQP4; MOG; MOGAD; NMOSD; SARS-CoV-2; Vaccination; Aquaporin 4; Autoantibodies; BNT162 Vaccine; COVID-19 Vaccines; Humans; Immunoglobulin G; Myelin-Oligodendrocyte Glycoprotein; Recurrence; Retrospective Studies; SARS-CoV-2; Vaccination; COVID-19; Neuromyelitis Optica
Elenco autori:
Dinoto, A.; Sechi, E.; Ferrari, S.; Gajofatto, A.; Orlandi, R.; Solla, P.; Maccabeo, A.; Maniscalco, G. T.; Andreone, V.; Sartori, A.; Manganotti, P.; Rasia, S.; Capra, R.; Mancinelli, C. R.; Mariotto, S.
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