Data di Pubblicazione:
2007
Citazione:
ACP1 and offspring sex ratio in smoking puerperae: a study at population level / GLORIA BOTTINI, F; Meloni, Gianfranco; Grassi, S; Bottini, N; Saccucci, P; Giarrizzo, Gf; Magrini, A; Bergamaschi, A; Bottini, E.. - In: EARLY HUMAN DEVELOPMENT. - ISSN 0378-3782. - 83:6(2007), pp. 349-354. [10.1016/j.earlhumdev.2006.07.005]
Abstract:
BACKGROUND: Data from previous study by our group suggest that in smoking women
sex ratio of offspring is higher in newborns carrying ACP1C allele than in other
ACP1 genotypes, suggesting that differences observed among human population
concerning the effect of smoking may depend in part on this genetic factor.
OBJECTIVES: In order to further explore this issue we have studied another
population and have analysed the relationship between sex ratio and ACP1C gene
frequency at population level.
METHODS: The analysis includes 719 consecutive births from Central Italy
considered in a previous paper and 5510 consecutive births from Sardinia. Data
from English and Japanese populations have also been considered in the analysis.
RESULTS: Among newborns not carrying ACP1C there is a decrease of SR among the
offspring of smoking mothers, while among newborns carrying the ACP1C allele
there is an increase of SR among the offspring of smoking mothers relative to
non-smoking mothers. Considering Sardinian, Italian, English and Japanese
population there is a linear positive relationship between C allele frequency and
SR in smoking mothers.
CONCLUSIONS: The present observation suggests an interaction between smoking and
ACP1 regarding their effects on sex ratio, by which the presence of the ACP1C
allele appears to counteract the effect of smoking. This suggests that genetic
background may modify the effects of toxic environmental factors on gamete
production and functionality and/or on intrauterine survival.
sex ratio of offspring is higher in newborns carrying ACP1C allele than in other
ACP1 genotypes, suggesting that differences observed among human population
concerning the effect of smoking may depend in part on this genetic factor.
OBJECTIVES: In order to further explore this issue we have studied another
population and have analysed the relationship between sex ratio and ACP1C gene
frequency at population level.
METHODS: The analysis includes 719 consecutive births from Central Italy
considered in a previous paper and 5510 consecutive births from Sardinia. Data
from English and Japanese populations have also been considered in the analysis.
RESULTS: Among newborns not carrying ACP1C there is a decrease of SR among the
offspring of smoking mothers, while among newborns carrying the ACP1C allele
there is an increase of SR among the offspring of smoking mothers relative to
non-smoking mothers. Considering Sardinian, Italian, English and Japanese
population there is a linear positive relationship between C allele frequency and
SR in smoking mothers.
CONCLUSIONS: The present observation suggests an interaction between smoking and
ACP1 regarding their effects on sex ratio, by which the presence of the ACP1C
allele appears to counteract the effect of smoking. This suggests that genetic
background may modify the effects of toxic environmental factors on gamete
production and functionality and/or on intrauterine survival.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
ACP; Sex ratio; Smoke
Elenco autori:
GLORIA BOTTINI, F; Meloni, Gianfranco; Grassi, S; Bottini, N; Saccucci, P; Giarrizzo, Gf; Magrini, A; Bergamaschi, A; Bottini, E.
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