Cap43 protein: an attractive motif for Ni(II) in the C-terminal domain

The carcinogenicity of nickel compounds has been confirmed by numerous epidemiological studies in humans and animals. A possible way to better understand the molecular mechanisms implicated in toxicity and carcinogenicity of nickel compounds is to study the characteristics of the proteins expressed by the genes specifically induced by these carcinogens.The present work supports the existence of an interesting binding site for Ni(II) at the C-terminal domain of Cap43 protein.