Infusion of casein hydrolizates into the mammary gland simulates the omission of one daily milking in goats

Suppression of one daily milking at weekends, even though socially desirable, may
reduce milk yield. These losses have been attributed to a short-term mechanism: the filling of the cistern and
ductal-alveolar system with milk which contains a peptide called feedback inhibitor of lactation (FIL) (Wilde
and Peaker, 1990). The FIL probably reduces the synthesis and secretion of mammary cells by blocking the
potassium channel of the apical membrane (Silanikoveet al., 2000). Shamayet al.(2002) hypothesized that
the FIL can be identified with the AA sequence 1-28, derived from the breakdown of β-casein by plasmin (PL).
The aim of this work was to verify if the infusion of casein hydrolizates (CNH) into the mammary gland simulates
the omission of one milking for two consecutive days.