Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV
Articolo
Data di Pubblicazione:
2020
Citazione:
Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV / Sanna, G; Madeddu, S; Serreli, G; Nguyen, Ht; Le, Nt; Usai, D; Carta, A; Cappuccinelli, P; Zanetti, S; Donadu, Mg. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2020), pp. 1-7. [10.1080/14786419.2020.1824228]
Abstract:
In the prevention of epidemic and pandemic emerging and
neglected viral infections, natural products are an important
source of lead compounds. Hornstedtia bella Skornickis is a
rhizomatous herb growing in the forest of central Vietnam.
Hornstedtia bella essential oil (Hb EO) was recently characterised
by our group as endowed of antimicrobial activity against
Staphylococcus aureus Methicillin-Resistant strains. Here, we
describe for the first time the evaluation of Hb EO against a spectrum
of viruses responsible for important human diseases. Hb EO
resulted active against Vaccinia virus (VV) (EC50 values 80 lg/mL),
closely related to variola virus, causative agent of smallpox. Hb
EO was able to strongly reduce the viral VV titer in cell-based
assay at not cytotoxic concentration and its potential mode of
action was characterised by virucidal activity evaluation followed
by time-of-addition assay. Furthermore, Hb EO antiviral activity
was implemented in a combination study with the mycophenolic
acid.
neglected viral infections, natural products are an important
source of lead compounds. Hornstedtia bella Skornickis is a
rhizomatous herb growing in the forest of central Vietnam.
Hornstedtia bella essential oil (Hb EO) was recently characterised
by our group as endowed of antimicrobial activity against
Staphylococcus aureus Methicillin-Resistant strains. Here, we
describe for the first time the evaluation of Hb EO against a spectrum
of viruses responsible for important human diseases. Hb EO
resulted active against Vaccinia virus (VV) (EC50 values 80 lg/mL),
closely related to variola virus, causative agent of smallpox. Hb
EO was able to strongly reduce the viral VV titer in cell-based
assay at not cytotoxic concentration and its potential mode of
action was characterised by virucidal activity evaluation followed
by time-of-addition assay. Furthermore, Hb EO antiviral activity
was implemented in a combination study with the mycophenolic
acid.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Viral infections; antiviral activity; essential oil; time of addition; vaccinia virus; combinations studies
Elenco autori:
Sanna, G; Madeddu, S; Serreli, G; Nguyen, Ht; Le, Nt; Usai, D; Carta, A; Cappuccinelli, P; Zanetti, S; Donadu, Mg
Link alla scheda completa:
Pubblicato in: