Interactions of Gold-based Drugs with Proteins: Structure and Stability of the Adduct Formed in the reaction between Lysozyme and the Cytotoxic Gold(III) Compound Auoxo3.
Articolo
Data di Pubblicazione:
2014
Citazione:
Interactions of Gold-based Drugs with Proteins: Structure and Stability of the Adduct Formed in the reaction between Lysozyme and the Cytotoxic Gold(III) Compound Auoxo3 / Russo Krauss, I; Messori, L; Cinellu, Maria Agostina; Marasco, D; Sirignano, R; Merlino, A.. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 43:(2014), pp. 17483-17488.
Abstract:
The structure and stability of the adduct formed in the reaction between Auoxo3, a dinuclear gold(III)
compound, and the model protein hen egg white lysozyme (HEWL) are investigated by X-ray crystallography,
UV-Vis absorption spectroscopy and circular dichroism (CD). It is found that Auoxo3 breaks down
completely, undergoes reduction and produces reactive gold(I) species able to bind the protein and form
stable derivatives. The behaviour of Auoxo3 is compared with that of two analogous gold(III) complexes
previously studied: a few significant differences are highlighted. The general implications of these new
results for the mode of action of cytotoxic gold complexes are discussed.
compound, and the model protein hen egg white lysozyme (HEWL) are investigated by X-ray crystallography,
UV-Vis absorption spectroscopy and circular dichroism (CD). It is found that Auoxo3 breaks down
completely, undergoes reduction and produces reactive gold(I) species able to bind the protein and form
stable derivatives. The behaviour of Auoxo3 is compared with that of two analogous gold(III) complexes
previously studied: a few significant differences are highlighted. The general implications of these new
results for the mode of action of cytotoxic gold complexes are discussed.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
gold-based drugs; lysozyme; X-ray structure
Elenco autori:
Russo Krauss, I; Messori, L; Cinellu, Maria Agostina; Marasco, D; Sirignano, R; Merlino, A.
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