Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles
Articolo
Data di Pubblicazione:
2020
Citazione:
Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles / Sanna, V.; Youssef, M. F.; Pala, N.; Rogolino, D.; Carcelli, M.; Singh, P. K.; Sanchez, T.; Neamati, N.; Sechi, M.. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 11:5(2020), pp. 857-861. [10.1021/acsmedchemlett.9b00648]
Abstract:
Gold nanoparticles (GNPs) have been proposed as carriers for drugs to improve their intrinsic therapeutic activities and to overcome pharmacokinetic problems. In this study, novel nanosystems constituted by a model β-diketo acid (DKA) grafted to the surface of GNPs were designed and synthesized following the "multivalent high-affinity"binding strategy. These first nanoscale DKA prototypes showed improved inhibition of HIV-1 integrase (HIV-1 IN) catalytic activities as compared with free DKA ligands.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
gold nanoparticles; HIV-1 integrase inhibitors; multivalent ligands; β-diketo acids
Elenco autori:
Sanna, V.; Youssef, M. F.; Pala, N.; Rogolino, D.; Carcelli, M.; Singh, P. K.; Sanchez, T.; Neamati, N.; Sechi, M.
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