Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis
Articolo
Data di Pubblicazione:
2020
Citazione:
Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis / Zinellu, A., Paliogiannis, P., Sotgiu, E., Mellino, S., Mangoni, A.A., Zinellu, E., Negri, S., Collu, C., Pintus, G., Serra, A., Pistuddi, A.M., Carru, C., Pirina, P., Fois, A.G.. - In: LUNG. - ISSN 0341-2040. - (2020). [10.1007/s00408-020-00386-7]
Abstract:
disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment.
However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain.
Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included
in this cross-sectional study.
Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio
(dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index
(SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression,
all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after
adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and
NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed.
Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation
in IPF.
However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain.
Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included
in this cross-sectional study.
Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio
(dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index
(SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression,
all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after
adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and
NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed.
Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation
in IPF.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Idiopathic pulmonary fibrosis · IPF · Inflammation · LMR · NLR · PLR
Elenco autori:
Zinellu, Angelo; Paliogiannis, Panagiotis; Sotgiu, Elisabetta; Mellino, Sabrina; Mangoni, Arduino A.; Zinellu, Elisabetta; Negri, Silvia; Collu, Claudia; Pintus, Gianfranco; Serra, Antonello; Pistuddi, Angelo Maria; Carru, Ciriaco; Pirina, Pietro; Fois, Alessandro G.
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