Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population.
Academic Article
Publication Date:
2018
Short description:
Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population / Masala M, Piras D; Delitala, A; Urru, Sam; Curreli, N; Balaci, L; Ferreli, Lp; Loi, F; Atzeni, A; Cabiddu, G; Racugno, W; Ventura, L; Zoledziewska, M; Steri, M; Fiorillo, E; Pilia, Mg; Schlessinger, D; Cucca, F; Rule, Ad; Pani, A.. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - 35:4(2018), pp. 640-647. [10.1093/ndt/gfy270]
abstract:
BACKGROUND: The relationship of kidney size to ageing, kidney function and kidney
disease risk factors is not fully understood.
METHODS: Ultrasound length and parenchymal kidney volume were determined from a
population-based sample of 3972 Sardinians (age range 18-100 years). We then
identified the subset of 2256 'healthy' subjects to define age- and sex-specific
reference ranges (2.5-97.5 percentile) of kidney volume. Logistic regression
(accounting for family clustering) was used to identify the clinical
characteristics associated with abnormally large kidneys or abnormally small
kidneys.
RESULTS: In the healthy subset, kidney volume and length increased up to the
fourth to fifth decade of life followed by a progressive decrease in men, whereas
there was a gradual kidney volume decrease throughout the lifespan of women. In
the whole sample, independent predictors of lower kidney volume (<2.5 percentile
for age and sex) were male sex, low body mass index, short height, low waist:hip
ratio and high serum creatinine (SCr); the independent predictors of larger
kidney volume (>97.5 percentile for age and sex) were younger age, female sex,
diabetes, obesity, high height, high waist:hip ratio and lower SCr. Estimated
heritability for kidney volume was 15%, and for length 27%; kidney volume
correlated strongly with birthweight.
CONCLUSIONS: Overall, in a general healthy population, kidney measures declined
with age differently in men and women. The determinants of kidney parenchymal
volume include genetic factors and modifiable clinical factors.
disease risk factors is not fully understood.
METHODS: Ultrasound length and parenchymal kidney volume were determined from a
population-based sample of 3972 Sardinians (age range 18-100 years). We then
identified the subset of 2256 'healthy' subjects to define age- and sex-specific
reference ranges (2.5-97.5 percentile) of kidney volume. Logistic regression
(accounting for family clustering) was used to identify the clinical
characteristics associated with abnormally large kidneys or abnormally small
kidneys.
RESULTS: In the healthy subset, kidney volume and length increased up to the
fourth to fifth decade of life followed by a progressive decrease in men, whereas
there was a gradual kidney volume decrease throughout the lifespan of women. In
the whole sample, independent predictors of lower kidney volume (<2.5 percentile
for age and sex) were male sex, low body mass index, short height, low waist:hip
ratio and high serum creatinine (SCr); the independent predictors of larger
kidney volume (>97.5 percentile for age and sex) were younger age, female sex,
diabetes, obesity, high height, high waist:hip ratio and lower SCr. Estimated
heritability for kidney volume was 15%, and for length 27%; kidney volume
correlated strongly with birthweight.
CONCLUSIONS: Overall, in a general healthy population, kidney measures declined
with age differently in men and women. The determinants of kidney parenchymal
volume include genetic factors and modifiable clinical factors.
Iris type:
1.1 Articolo in rivista
Keywords:
age; elderly; epidemiology; gender; ultrasonography
List of contributors:
Masala M, Piras D; Delitala, A; Urru, Sam; Curreli, N; Balaci, L; Ferreli, Lp; Loi, F; Atzeni, A; Cabiddu, G; Racugno, W; Ventura, L; Zoledziewska, M; Steri, M; Fiorillo, E; Pilia, Mg; Schlessinger, D; Cucca, F; Rule, Ad; Pani, A.
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