[123I]Metaiodobenzylguanidine (MIBG) Cardiac Scintigraphy and Automated Classification Techniques in Parkinsonian Disorders.
Articolo
Data di Pubblicazione:
2020
Citazione:
[123I]Metaiodobenzylguanidine (MIBG) Cardiac Scintigraphy and Automated
Classification Techniques in Parkinsonian Disorders / Nuvoli, Susanna Maria Francesca; Spanu, Angela; Fravolini Mario, Luca; Bianconi, Francesco; Cascianelli, Silvia; Madeddu, Giuseppe; Palumbo, Barbara.. - In: MOLECULAR IMAGING AND BIOLOGY. - ISSN 1536-1632. - 22:(2020), pp. 703-710. [10.1007/s11307-019-01406-6]
Abstract:
PURPOSE: To provide reliable and reproducible heart/mediastinum (H/M) ratio
cut-off values for parkinsonian disorders using two machine learning techniques,
Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to
[123I]MIBG cardiac scintigraphy.
PROCEDURES: We studied 85 subjects, 50 with idiopathic Parkinson's disease, 26
with atypical Parkinsonian syndromes (P), and 9 with essential tremor (ET). All
patients underwent planar early and delayed cardiac scintigraphy after [123I]MIBG
(111 MBq) intravenous injection. Images were evaluated both qualitatively and
quantitatively; the latter by the early and delayed H/M ratio obtained from
regions of interest (ROIt1 and ROIt2) drawn on planar images. SVM and RF
classifiers were finally used to obtain the correct cut-off value.
RESULTS: SVM and RF produced excellent classification performances: SVM
classifier achieved perfect classification and RF also attained very good
accuracy. The better cut-off for H/M value was 1.55 since it remains the same for
both ROIt1 and ROIt2. This value allowed to correctly classify PD from P and ET:
patients with H/M ratio less than 1.55 were classified as PD while those with
values higher than 1.55 were considered as affected by parkinsonism and/or ET. No
difference was found when early or late H/M ratio were considered separately thus
suggesting that a single early evaluation could be sufficient to obtain the final
diagnosis.
CONCLUSIONS: Our results evidenced that the use of SVM and CT permitted to define
the better cut-off value for H/M ratios both in early and in delayed phase thus
underlining the role of [123I]MIBG cardiac scintigraphy and the effectiveness of
H/M ratio in differentiating PD from other parkinsonism or ET. Moreover, early
scans alone could be used for a reliable diagnosis since no difference was found
between early and late. Definitely, a larger series of cases is needed to confirm
this data.
cut-off values for parkinsonian disorders using two machine learning techniques,
Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to
[123I]MIBG cardiac scintigraphy.
PROCEDURES: We studied 85 subjects, 50 with idiopathic Parkinson's disease, 26
with atypical Parkinsonian syndromes (P), and 9 with essential tremor (ET). All
patients underwent planar early and delayed cardiac scintigraphy after [123I]MIBG
(111 MBq) intravenous injection. Images were evaluated both qualitatively and
quantitatively; the latter by the early and delayed H/M ratio obtained from
regions of interest (ROIt1 and ROIt2) drawn on planar images. SVM and RF
classifiers were finally used to obtain the correct cut-off value.
RESULTS: SVM and RF produced excellent classification performances: SVM
classifier achieved perfect classification and RF also attained very good
accuracy. The better cut-off for H/M value was 1.55 since it remains the same for
both ROIt1 and ROIt2. This value allowed to correctly classify PD from P and ET:
patients with H/M ratio less than 1.55 were classified as PD while those with
values higher than 1.55 were considered as affected by parkinsonism and/or ET. No
difference was found when early or late H/M ratio were considered separately thus
suggesting that a single early evaluation could be sufficient to obtain the final
diagnosis.
CONCLUSIONS: Our results evidenced that the use of SVM and CT permitted to define
the better cut-off value for H/M ratios both in early and in delayed phase thus
underlining the role of [123I]MIBG cardiac scintigraphy and the effectiveness of
H/M ratio in differentiating PD from other parkinsonism or ET. Moreover, early
scans alone could be used for a reliable diagnosis since no difference was found
between early and late. Definitely, a larger series of cases is needed to confirm
this data.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Nuvoli, Susanna Maria Francesca; Spanu, Angela; Fravolini Mario, Luca; Bianconi, Francesco; Cascianelli, Silvia; Madeddu, Giuseppe; Palumbo, Barbara.
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