Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin
Articolo
Data di Pubblicazione:
2005
Citazione:
Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin / Zanetti, Stefania Anna Lucia; Bua, Alessandra; Delogu, G; Pusceddu, C; Mura, M; Saba, F; Pirina, Pietro; Garzelli, C; Vertuccio, C; Sechi, Leonardo Antonio; Fadda, G.. - In: CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. - ISSN 1071-412X. - 12:9(2005), pp. 1135-1138. [10.1128/CDLI.12.9.1135-1138.2005]
Abstract:
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Antibodies; Bacterial; Antibody Formation; Antibody Specificity; Antigens; Enzyme-Linked Immunosorbent Assay; Hemagglutinins; Humans; Lectins; Methylation; Mycobacterium tuberculosis; Recombinant Proteins; Tuberculosis; Pulmonary
Elenco autori:
Zanetti, Stefania Anna Lucia; Bua, Alessandra; Delogu, G; Pusceddu, C; Mura, M; Saba, F; Pirina, Pietro; Garzelli, C; Vertuccio, C; Sechi, Leonardo Antonio; Fadda, G.
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