Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art
Academic Article
Publication Date:
2018
Short description:
Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art / Zinellu, A., Fois, A.G., Mangoni, A.A., Paliogiannis, P., Sotgiu, E., Zinellu, E., Marras, V., Pirina, P., Carru, C.. - In: AMINO ACIDS. - ISSN 0939-4451. - 50:9(2018), pp. 1169-1176. [10.1007/s00726-018-2606-7]
abstract:
Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.
Iris type:
1.1 Articolo in rivista
Keywords:
ADMA; Arginine; Chronic obstructive pulmonary disease; Inflammation; Oxidative stress; Animals; Arginine; Humans; Nitric Oxide Synthase; Pulmonary Disease, Chronic Obstructive; Oxidative Stress; Biochemistry; Clinical Biochemistry; Organic Chemistry
List of contributors:
Zinellu, Angelo; Fois, Alessandro G.; Mangoni, Arduino A.; Paliogiannis, Panagiotis; Sotgiu, Elisabetta; Zinellu, Elisabetta; Marras, Viviana; Pirina, Pietro; Carru, Ciriaco
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