Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: A systematic review and meta-analysis

Academic Article

Publication Date:

2018

Short description:

Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: A systematic review and meta-analysis / Paliogiannis, P., Fois, A.G., Collu, C., Bandinu, A., Zinellu, E., Carru, C., Pirina, P., Mangoni, A.A., Zinellu, A.. - In: BIOMARKERS IN MEDICINE. - ISSN 1752-0363. - 12:10(2018), pp. 1175-1184. [10.2217/bmm-2018-0108]

abstract:

Aim: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. Methods: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. Results: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. Conclusion: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.

Iris type:

1.1 Articolo in rivista

Keywords:

bronchoalveolar lavage fluid; epithelial lining fluid; expired breath condensate; glutathione; hydroperoxides; idiopathic pulmonary fibrosis; isoprostanes; lung; oxidative stress; protein carbonyls; systemic; thiobarbituric acid reactive substances; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Biochemistry (medical)

List of contributors: