Data di Pubblicazione:
2010
Citazione:
IN VIVO RIBAVIRIN ACTIVITY AGAINST SEVERE PANDEMIC H1N1 INFLUENZA A/MEXICO/4108/2009 / Rowe, T; Banner, D; Farooqui, A; Ng, D. C. K.; Kelvin, A. A.; Rubino, Salvatore; Huang, S. S.; Fang, Y; Kelvin, D. J.. - In: JOURNAL OF GENERAL VIROLOGY. - ISSN 0022-1317. - 91:(2010), pp. 2898-2906.
Abstract:
The use of ribavirin in influenza treatment is a matter of debate. Due to adamantine- and
oseltamivir-resistant strains of the current pandemic H1N1 (pdmH1N1) influenza viruses, the
demand for alternative antiviral treatments has increased. This study demonstrated the potent
antiviral effects of ribavirin in a mouse model of pdmH1N1 influenza infection (A/Mexico/4108/
2009). It was found that treatment with 40 mg ribavirin kg”1 day”1 partially protected the animals
if initiated immediately upon infection. Administration of similar concentrations on subsequent
days or immediate therapy with lower doses efficiently delayed disease progression. Correlation
studies showed a direct relationship between low viral titres in the lung during the early stages of
infection with animal survival in ribavirin-treated animals. Reduced lung pathology in animals
treated with ribavirin following infection also indicated the importance of immediate treatment. This
study revealed the antiviral properties of ribavirin and these results justify comprehensive clinical
studies for the use of ribavirin against influenza virus in future outbreaks.
oseltamivir-resistant strains of the current pandemic H1N1 (pdmH1N1) influenza viruses, the
demand for alternative antiviral treatments has increased. This study demonstrated the potent
antiviral effects of ribavirin in a mouse model of pdmH1N1 influenza infection (A/Mexico/4108/
2009). It was found that treatment with 40 mg ribavirin kg”1 day”1 partially protected the animals
if initiated immediately upon infection. Administration of similar concentrations on subsequent
days or immediate therapy with lower doses efficiently delayed disease progression. Correlation
studies showed a direct relationship between low viral titres in the lung during the early stages of
infection with animal survival in ribavirin-treated animals. Reduced lung pathology in animals
treated with ribavirin following infection also indicated the importance of immediate treatment. This
study revealed the antiviral properties of ribavirin and these results justify comprehensive clinical
studies for the use of ribavirin against influenza virus in future outbreaks.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Rowe, T; Banner, D; Farooqui, A; Ng, D. C. K.; Kelvin, A. A.; Rubino, Salvatore; Huang, S. S.; Fang, Y; Kelvin, D. J.
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