A MOF-based carrier for in situ dopamine delivery

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing
superparamagnetic nanoparticles to assemble a new class of biocompatible particles for
magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine
protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After
loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring
via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based
carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells
as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side
effects due to oxidation occurring in the extracellular environment.