Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's Disease
Articolo
Data di Pubblicazione:
2015
Citazione:
Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's Disease / De Natale, Er; Ginatempo, F; Paulus, Ks; Manca, A; Mercante, B; Pes, Giovanni Mario; Agnetti, V; Tolu, Eusebio; Deriu, Franca. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 126:15(2015), pp. 1871-1878. [10.1016/j.clinph.2014.12.017]
Abstract:
OBJECTIVE:
To study brainstem function in Parkinson's Disease (PD) at different stages, through a battery of vestibular-evoked myogenic potentials (VEMPs) and compare the results with scores on clinical scales assessing the presence of symptoms linked to brainstem involvement.
METHODS:
Cervical, masseter and ocular VEMPs were recorded in patients with early PD (n=14, disease duration 1.42±0.7years), advanced PD (n=19, disease duration 7.26±2.9years) and in 27 age-matched controls. In PD, the following clinical scales were administered: Mini-BESTest, REM sleep Behavior Disorder Screening Questionnaire (RBD-SQ), PD Sleep Scale, Epworth Sleepiness Scale and Geriatric Depression Scale.
RESULTS:
Rate of VEMPs alterations was higher (p<0.001) in PD than controls, but similar within PD groups. However, early and advanced PD showed a different pattern of abnormalities (p=0.02), being latency delay prevalent in the former and absence in the latter. VEMP impairment correlated directly with RBD-SQ scores in both PD cohorts and inversely with Mini-BESTest scores in advanced PD.
CONCLUSIONS:
VEMPs displayed progressive severity of alterations at different stages of PD, with remarkable correlations with presence of postural instability and RBD.
SIGNIFICANCE:
The combined use of VEMPs may provide interesting insights into the pathophysiological mechanisms of PD at the earliest and prodromal stage of the disease.
Copyright © 2015. Published by Elsevier Ireland Ltd.
To study brainstem function in Parkinson's Disease (PD) at different stages, through a battery of vestibular-evoked myogenic potentials (VEMPs) and compare the results with scores on clinical scales assessing the presence of symptoms linked to brainstem involvement.
METHODS:
Cervical, masseter and ocular VEMPs were recorded in patients with early PD (n=14, disease duration 1.42±0.7years), advanced PD (n=19, disease duration 7.26±2.9years) and in 27 age-matched controls. In PD, the following clinical scales were administered: Mini-BESTest, REM sleep Behavior Disorder Screening Questionnaire (RBD-SQ), PD Sleep Scale, Epworth Sleepiness Scale and Geriatric Depression Scale.
RESULTS:
Rate of VEMPs alterations was higher (p<0.001) in PD than controls, but similar within PD groups. However, early and advanced PD showed a different pattern of abnormalities (p=0.02), being latency delay prevalent in the former and absence in the latter. VEMP impairment correlated directly with RBD-SQ scores in both PD cohorts and inversely with Mini-BESTest scores in advanced PD.
CONCLUSIONS:
VEMPs displayed progressive severity of alterations at different stages of PD, with remarkable correlations with presence of postural instability and RBD.
SIGNIFICANCE:
The combined use of VEMPs may provide interesting insights into the pathophysiological mechanisms of PD at the earliest and prodromal stage of the disease.
Copyright © 2015. Published by Elsevier Ireland Ltd.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Brainstem, Parkinson’s Disease, Vestibular-evoked myogenic potentials, Vestibulo-collic reflex, Vestibulo-masseteric reflex, Vestibulo-ocular reflex
Elenco autori:
De Natale, Er; Ginatempo, F; Paulus, Ks; Manca, A; Mercante, B; Pes, Giovanni Mario; Agnetti, V; Tolu, Eusebio; Deriu, Franca
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