Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium
Academic Article
Publication Date:
2014
Short description:
Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium / Santona, A., Paglietti, B., Al Qahtani, A.A., Bohol, M.F.F., Senok, A., Deligios, M., Rubino, S., Al Ahdal, M.N.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 44:2(2014), pp. 156-159. [10.1016/j.ijantimicag.2014.05.005]
abstract:
Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Iris type:
1.1 Articolo in rivista
Keywords:
MLST; Hospital-associated; Enterococcus faecium; Teicoplanin resistance mechanism
List of contributors:
Santona, Antonella; Paglietti, Bianca; Al Qahtani, Ahmed A.; Bohol, Marie Fe F.; Senok, Abiola; Deligios, Massimo; Rubino, Salvatore; Al Ahdal, Mohammed N.
Published in: