Publication Date:
2005
Short description:
Search for the pharmacophore in prazosin for Transport-P / PATRICIA A., Z., Cesare, F., Sechi, M., SAAD AL, D., C., R.G.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 13:(2005), pp. 3681-3689.
abstract:
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural
features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-
amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-
amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
Iris type:
1.1 Articolo in rivista
List of contributors:
PATRICIA A., Zunszain; Cesare, Federico; Sechi, Mario; SAAD AL, Damluji; C., ROBIN GANELLIN
Published in: