Regulation of calf thymus cytosolic 5'-nucleotidase/nucleoside phosphotransferase

Many phosphatases with different specificity and cellular location have been described to be able to catalyze a phosphotransferase reaction1, 2 as well as several enzymes named phosphotransferases have been demonstrated to hydrolyze phosphoesters3, 4. Even though a number of papers and very accurate reviews have been published on phosphohydrolases, particularly on nucleotidases classified following their substrate specificity or cellular location, still additional information is needed on the molecular characteristics and on the regulation of the phosphohydrolase/phosphotransferases in order to understand the role, if any, of their potential bifunctionality.