Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents.
Academic Article
Publication Date:
2009
Short description:
Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents / Dallocchio, R., Dessì, A., Sanna, V.A., Pala, N., Campesi, I., Paglietti, G.S.M.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 6:4(2009), pp. 246-251. [10.2174/157018009788452537]
abstract:
The ability of the docking program AutoDock in studying the binding of small molecules to DNA is examined.
Herein, we report molecular dynamic studies with the relaxed complex method applied to DNA, and viscosimetric titration
results, performed to investigate a possible DNA-binding mode of a model compound of the previously reported “two
armed” class of binders.
Herein, we report molecular dynamic studies with the relaxed complex method applied to DNA, and viscosimetric titration
results, performed to investigate a possible DNA-binding mode of a model compound of the previously reported “two
armed” class of binders.
Iris type:
1.1 Articolo in rivista
List of contributors:
Dallocchio, R; Dessì, A; Sanna, Vanna Annunziata; Pala, N; Campesi, Ilaria; Paglietti, G. Sechi M.
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