Synthesis of (2R,5S)- and (2S, SS)-2-Carboxy-l,4-diaza- [4.3.0]bicyclononane as Building Blocks for the Synthesis of New Potential HIV Protease Inhibitors.
Academic Article
Publication Date:
1996
Short description:
Synthesis of (2R,5S)- and (2S, SS)-2-Carboxy-l,4-diaza-
[4.3.0]bicyclononane as Building Blocks for the Synthesis of New
Potential HIV Protease Inhibitors / Porcheddu, A., Giacomelli, G., Falorni, M.. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 7:7(1996), pp. 1999-2005. [10.1016/0957-4166(96)00241-8]
abstract:
A procedure for the preparation of optically active (2R,5S)- and (2S,5S)-2-
Carboxy-l,4-diaza-[4.3.0]bicyclononane is described. The method is based on the
reduction of diketopiperazines obtained from cyclization of Pro-L-Ser or Pro-D-Set
and occurs without loss of enantiomedc purity. The synthesis is based on readily
available starting materials and can be easily arranged for multigram scale preparations.
Carboxy-l,4-diaza-[4.3.0]bicyclononane is described. The method is based on the
reduction of diketopiperazines obtained from cyclization of Pro-L-Ser or Pro-D-Set
and occurs without loss of enantiomedc purity. The synthesis is based on readily
available starting materials and can be easily arranged for multigram scale preparations.
Iris type:
1.1 Articolo in rivista
List of contributors:
Porcheddu, Andrea; Giacomelli, G; Falorni, M.
Published in: