PHARMACOKINETICANDPHARMACODYNAMIC ASSESSMENTSOFTAPENTADOLINYELLOW-BELLIED SLIDER TURTLES(TRACHEMYS SCRIPTASCRIPTA) AFTER ASINGLEINTRAMUSCULARINJECTION
Articolo
Data di Pubblicazione:
2015
Citazione:
PHARMACOKINETICANDPHARMACODYNAMIC
ASSESSMENTSOFTAPENTADOLINYELLOW-BELLIED
SLIDER TURTLES(TRACHEMYS SCRIPTASCRIPTA)
AFTER ASINGLEINTRAMUSCULARINJECTION / Giorgi, M; Lee HK Rota, S; Owen, H; Vito, De; Virginia, ; Demontis, Maria Piera; Varoni, Maria Vittoria. - In: JOURNAL OF EXOTIC PET MEDICINE. - ISSN 1557-5063. - 24:(2015), pp. 317-325. [10.1053/j.jepm.2015.06.004]
Abstract:
In reptiles,administrationofopioiddrugshasyieldedunexpectedresultswithrespecttoanalgesia.
Tapentadol(TAP)isanovelatypicalopioiddruglabelledforhumanuse.Theobjectiveofthisstudywas
to evaluatethepharmacokineticsandthepharmacodynamicsofthisdruginyellow-belliedsliders,aftera
single intramuscular(IM)injectionof5mg/kgofTAP.Turtles(n ¼ 9) wererandomlyassignedto2
treatment groups,accordingtoasingle-dose,single-treatment,unpaired,2-periodcrossoverdesign.
Group A(n ¼ 5) receivedasingleIM(proximalfrontlimb)doseofTAP(5mg/mL)at5mg/kg.GroupB
(n ¼ 4) receivedasingleIMinjectionofsaline(equivalentvolumetoopioidvolumes)ofTAPatthesame
site. Aftera1-monthwashoutperiod,groupswererotatedandtheexperimentrepeated.TAPplasma
concentrationsweredeterminedbyavalidatedhigh-performanceliquidchromatography-fluorescence
method, andaninfraredthermalstimuliwasappliedtotheplantarsurfaceoftheturtles’ hind limbsto
evaluatethethermalwithdrawallatency(TWL).TAPplasmaconcentrationsweredetectablebetween1
and 24hour(s)(1619and37ng/mL,respectively).TheTAP-treatedgroupshowedanincreaseinTWL1
hour afterdrugadministration(13.32 6.40 seconds).Subsequently,TWLdecreasedwithtimeand
significant differencesbetweentreatmentandcontrolgroupswereapparentupto10hoursfollowing
treatment. Alinearrelationship(r2 ¼ 0.99)betweenTAPplasmaconcentrationandeffectwasfound.
Given these findings,TAPappearstobeanattractiveoptionforantinociceptioninturtles,owingtoits
rapid onsetandacceptabledurationofeffect.
Tapentadol(TAP)isanovelatypicalopioiddruglabelledforhumanuse.Theobjectiveofthisstudywas
to evaluatethepharmacokineticsandthepharmacodynamicsofthisdruginyellow-belliedsliders,aftera
single intramuscular(IM)injectionof5mg/kgofTAP.Turtles(n ¼ 9) wererandomlyassignedto2
treatment groups,accordingtoasingle-dose,single-treatment,unpaired,2-periodcrossoverdesign.
Group A(n ¼ 5) receivedasingleIM(proximalfrontlimb)doseofTAP(5mg/mL)at5mg/kg.GroupB
(n ¼ 4) receivedasingleIMinjectionofsaline(equivalentvolumetoopioidvolumes)ofTAPatthesame
site. Aftera1-monthwashoutperiod,groupswererotatedandtheexperimentrepeated.TAPplasma
concentrationsweredeterminedbyavalidatedhigh-performanceliquidchromatography-fluorescence
method, andaninfraredthermalstimuliwasappliedtotheplantarsurfaceoftheturtles’ hind limbsto
evaluatethethermalwithdrawallatency(TWL).TAPplasmaconcentrationsweredetectablebetween1
and 24hour(s)(1619and37ng/mL,respectively).TheTAP-treatedgroupshowedanincreaseinTWL1
hour afterdrugadministration(13.32 6.40 seconds).Subsequently,TWLdecreasedwithtimeand
significant differencesbetweentreatmentandcontrolgroupswereapparentupto10hoursfollowing
treatment. Alinearrelationship(r2 ¼ 0.99)betweenTAPplasmaconcentrationandeffectwasfound.
Given these findings,TAPappearstobeanattractiveoptionforantinociceptioninturtles,owingtoits
rapid onsetandacceptabledurationofeffect.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Giorgi, M; Lee HK Rota, S; Owen, H; Vito, De; Virginia, ; Demontis, Maria Piera; Varoni, Maria Vittoria
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