Prevalence of Respiratory Symptoms and Screening for Chronic Obstructive Pulmonary Disease: Results from an Italian Multicenter Study
Abstract
Publication Date:
2015
Short description:
Prevalence of Respiratory Symptoms and Screening for Chronic Obstructive Pulmonary Disease: Results from an Italian Multicenter Study / Fois, Ag; Bagella, P; Ricci, E; Farenga, M; Martinelli, C; De Socio, Gv; Bellacosa, C; Celesia, Bm; Menzaghi, B; Franzetti, M; Bonfanti, P; Madeddu, Giordano. - (2015). (Intervento presentato al convegno 15th European AIDS Conference tenutosi a Barcellona nel 21-24 October 2015).
abstract:
Objectives: We aimed to evaluate the prevalence of chronic respiratory symptoms and to perform a screening for Chronic
Obstructive Pulmonary Disease (COPD) in a cohort of HIV-infected patients.
Methods: The COPS study is a prospective, observational, multicentre study. Screening for COPD was performed using the 5-
item GOLD questionnaire. Patients with ≥3 positive answers were considered as probable COPD (pCOPD).
Results: A total of 687 HIV-infected patients with a mean age of 47.7 ± 9.9 years were enrolled, of these 513 (74.7%) were
male, 639 (93.0%) Caucasians and 158 (23.4%) were previous intravenous drug-users (IDU). Mean CD4 cell count was 679 ±
348 cells/mm3, HIV-RNA was undetectable in 511 (75.9%) and 39 (5.7%) were naive. In 192 (28.1%) patients a chronic
hepatitis was also present.
Regarding respiratory symptoms 131 (19.1%) reported chronic cough, 148 (21.5%) sputum and 140 (20.4%) dyspnoea.
Furthermore, 558 (81.3%) were older than 40 years old and 500 (72.9%) where current/previous smokers.
According to the GOLD questionnaire, 215 (31.2%) patients were considered as pCOPD.
At univariate analysis, patients with pCOPD were significantly older (p< 0.0001) and more frequently current/previous smokers
(p< 0.0001), previous IDU (p=0.0006), had a current/past alcohol abuse (p< 0.0001), a history of pulmonary infection (p<
0.0001), a chronic hepatitis (p< 0.0001) and were less frequently naive to antiretrovirals (p=0.009).
At multivariate analysis, pCOPD was associated with older age (OR 1.16, CI 1.048-1.285), previous (OR 2.77, CI 1.442-5.321)
or current smoking (OR 9.80, CI 5.45-17.64), previous pulmonary infection (OR 1.86, CI 1.21-2.86), naive status (OR 0.32, CI
0.12-0.87) and chronic hepatitis (OR 1.52, CI 1.02-2.27).
Conclusion: Our data show a high prevalence of chronic respiratory symptoms and pCOPD in a HIV-infected outpatient
population. Smoking cessation and early cART initiation could represent a comprehensive strategy to reduce the burden of
COPD in the HIV-infected population.
Obstructive Pulmonary Disease (COPD) in a cohort of HIV-infected patients.
Methods: The COPS study is a prospective, observational, multicentre study. Screening for COPD was performed using the 5-
item GOLD questionnaire. Patients with ≥3 positive answers were considered as probable COPD (pCOPD).
Results: A total of 687 HIV-infected patients with a mean age of 47.7 ± 9.9 years were enrolled, of these 513 (74.7%) were
male, 639 (93.0%) Caucasians and 158 (23.4%) were previous intravenous drug-users (IDU). Mean CD4 cell count was 679 ±
348 cells/mm3, HIV-RNA was undetectable in 511 (75.9%) and 39 (5.7%) were naive. In 192 (28.1%) patients a chronic
hepatitis was also present.
Regarding respiratory symptoms 131 (19.1%) reported chronic cough, 148 (21.5%) sputum and 140 (20.4%) dyspnoea.
Furthermore, 558 (81.3%) were older than 40 years old and 500 (72.9%) where current/previous smokers.
According to the GOLD questionnaire, 215 (31.2%) patients were considered as pCOPD.
At univariate analysis, patients with pCOPD were significantly older (p< 0.0001) and more frequently current/previous smokers
(p< 0.0001), previous IDU (p=0.0006), had a current/past alcohol abuse (p< 0.0001), a history of pulmonary infection (p<
0.0001), a chronic hepatitis (p< 0.0001) and were less frequently naive to antiretrovirals (p=0.009).
At multivariate analysis, pCOPD was associated with older age (OR 1.16, CI 1.048-1.285), previous (OR 2.77, CI 1.442-5.321)
or current smoking (OR 9.80, CI 5.45-17.64), previous pulmonary infection (OR 1.86, CI 1.21-2.86), naive status (OR 0.32, CI
0.12-0.87) and chronic hepatitis (OR 1.52, CI 1.02-2.27).
Conclusion: Our data show a high prevalence of chronic respiratory symptoms and pCOPD in a HIV-infected outpatient
population. Smoking cessation and early cART initiation could represent a comprehensive strategy to reduce the burden of
COPD in the HIV-infected population.
Iris type:
4.2 Abstract in Atti di convegno
List of contributors:
Fois, Ag; Bagella, P; Ricci, E; Farenga, M; Martinelli, C; De Socio, Gv; Bellacosa, C; Celesia, Bm; Menzaghi, B; Franzetti, M; Bonfanti, P; Madeddu, Giordano
Book title:
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