Publication Date:
2015
Short description:
Interaction of selected gold(III) complexes with DNA G quadruplexes / Gratteri, P; Massai, L; Michelucci, E; Rigo, R; Messori, L; Cinellu, Maria Agostina; Musetti, C; Sissi, C; Bazzicalupi, C.. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 44:(2015), pp. 3633-3639.
abstract:
The interactions of three representative gold(III) complexes with human telomeric DNA sequences were
analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI
MS; remarkable interactions were highlighted for all tested complexes, although they were associated to
significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III)
complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation,
turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear
the way for novel biological and pharmacological applications of this class of metal compounds.
analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI
MS; remarkable interactions were highlighted for all tested complexes, although they were associated to
significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III)
complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation,
turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear
the way for novel biological and pharmacological applications of this class of metal compounds.
Iris type:
1.1 Articolo in rivista
Keywords:
gold complexes; G quadruplex DNA; cytotoxic derivatives
List of contributors:
Gratteri, P; Massai, L; Michelucci, E; Rigo, R; Messori, L; Cinellu, Maria Agostina; Musetti, C; Sissi, C; Bazzicalupi, C.
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