Genome-based analysis for the identification of candidate genes associated with skin-photosensitization tolerance in sheep

In ruminant livestock, skin photosensitization, caused by the ingestion of toxic plants, is relatively common and affects animal production. In this study, genotyping data from the Illumina OvineSNP50 BeadChip from two Italian local sheep breeds (Leccese and Altamurana) were used to identify putative genomic regions associated with response to skin photosensitization. We identified four genomic regions harbouring several candidate genes related to dermatitis, immune response, and coat color, that could be potentially involved in modulating photosensitization in sheep. These findings enhance our understanding of the genetic mechanisms underlying skin photosensitization in sheep and provide valuable insights into livestock adaptation to local environmental pressure.