Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide
Academic Article
Publication Date:
1993
Short description:
Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide / Mattana, A., Juliano, C.C.A., V., P., F., F., P., C.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 16:4(1993), pp. 359-365.
abstract:
The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2).
Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.
Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.
Iris type:
1.1 Articolo in rivista
List of contributors:
Mattana, Antonella; Juliano, Claudia Clelia Assunta; V., Picci; F., Franconi; P., Cappuccinelli
Published in: