NHC-gold(I)-alkyne complexes induced hepatocellular carcinoma cell death through bioorthogonal activation by palladium complex in living system
Academic Article
Publication Date:
2023
Short description:
NHC-gold(I)-alkyne complexes induced hepatocellular carcinoma cell death through bioorthogonal activation by palladium complex in living system / Lu, Y., Liu, Y., Liang, Z., Ma, X., Liu, L., Wen, Z., Tolbatov, I., Marrone, A., Liu, W.. - In: CHINESE CHEMICAL LETTERS. - ISSN 1001-8417. - 34:9(2023). [10.1016/j.cclet.2023.108413]
abstract:
Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes. In this study, Pd(PPh3)2Cl2 was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene (NHC)-gold(I)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase (TrxR) and exhibit significant anticancer bioactivity in hepatocellular carcinoma (HCC).& COPY; 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Iris type:
1.1 Articolo in rivista
Keywords:
Hepatocellular carcinoma; N-Heterocyclic carbene; Gold complex; Alkyne; Bioorthogonal activation
List of contributors:
Lu, Yunlong; Liu, Yuanhao; Liang, Zhenlin; Ma, Xiaoyan; Liu, Lijuan; Wen, Zhenfan; Tolbatov, Iogann; Marrone, Alessandro; Liu, Wukun
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