Publication Date:
1994
Short description:
Cyclopenta[e][1,5]benzodiazepin-10(9H)-one derivatives as CNS depressant agents / A., M., G., P., M. D., M., F., S., A., B., M., S., Peana, A.T.. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 133:3(1994), pp. 167-172.
abstract:
A series of dialkylaminoalkyl derivatives of cyclopenta[e][1,5] benzodiazepin-10(9H)-one (E1-4) and its 6-chloro derivative (E5-8) was prepared to evaluate their CNS activity in comparison with that of isosteric pyridodiazepinones (A1-4) previously described. The results of the pharmacological screening show a significant depressant activity more remarkable in 6-chloro derivatives, which also revealed a high and lasting analgesic activity. The replacement of pyridine with benzene nucleus did not show any significant or homogeneous activity variation.
Iris type:
1.1 Articolo in rivista
List of contributors:
A., Mule'; G., Pirisino; M. D., Moretti; F., Savelli; A., Boido; M., Satta; Peana, Alessandra Tiziana
Published in: