Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors
Academic Article
Publication Date:
2008
Short description:
Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors / Sechi, M., Azzena, U.G., MARIA PAOLA, D., Roberto, D., Alessandro, D., Alessia, C., Nicolino, P., Nouri, N.. - In: MOLECULES. - ISSN 1420-3049. - 13:(2008), pp. 2442-2461. [10.3390/molecules13102442]
abstract:
HIV-1 integrase (IN) is an attractive and validated target for the development of
novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and
synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid.
We performed a docking study to investigate the potential interactions of the title
compounds with essential amino acids on the IN active site.
novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and
synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid.
We performed a docking study to investigate the potential interactions of the title
compounds with essential amino acids on the IN active site.
Iris type:
1.1 Articolo in rivista
Keywords:
Bis-amides; HIV-1; HIV-1 integrase
List of contributors:
Sechi, Mario; Azzena, Ugo Gavino; MARIA PAOLA, Delussu; Roberto, Dallocchio; Alessandro, Dessì; Alessia, Cosseddu; Nicolino, Pala; Nouri, Neamati
Published in: