Publication Date:
2007
Short description:
Glucose-6-phosphate dehydrogenase deficiency in retinal vein occlusion / Pinna, Antonio; Carru, Ciriaco; Solinas, Maria Giuliana; Zinellu, A; Carta, F.. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - 48:6(2007), pp. 2747-2752. [10.1167/iovs.06-1064]
abstract:
PURPOSE. Glucose-6-phosphate dehydrogenase (G6PD) defi-
ciency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against
ischemic heart and cerebrovascular disease. The purpose of
this study was to assess the frequency of G6PD deficiency in
Sardinian patients with retinal vein occlusion (RVO) and to
ascertain whether the deficiency may offer protection against
RVO.
METHODS. Erythrocyte G6PD levels were measured in 448 consecutive RVO patients: 194 with central RVO (CRVO) and 254
with branch RVO (BRVO). Age- and sex-matched subjects (n
896) who were undergoing cataract surgery and had no history
of RVO served as the control. Multiple logistic regression models were used to investigate the association between G6PD
deficiency and RVO, CRVO, or BRVO.
RESULTS. G6PD deficiency was found in 21 (4.7%) patients with
RVO, 7 (3.6%) with CRVO, 14 (5.5%) with BRVO, and 107
(11.9%) control subjects. Differences between cases and controls were statistically significant (P 0.005). Multiple conditional logistic regression analysis, including as covariates G6PD
deficiency, hypertension, diabetes, and hypercholesterolemia,
revealed that G6PD deficiency was significantly associated with
decreased risk of development of RVO, CRVO, or BRVO. After
adjustment for hypertension, diabetes, and hypercholesterolemia, the association between G6PD deficiency and RVO,
CRVO, or BRVO remained statistically significant. Similar results were obtained after adjustment for systolic or diastolic
blood pressure, plasma glucose, and cholesterol levels. However, when the patients with CRVO or BRVO were categorized
by gender, a significant association was found only in the
women.
CONCLUSIONS. The frequency of G6PD deficiency in patients
with RVO was significantly lower than expected. The results
suggest that G6PD-deficient patients have a significantly decreased risk of development of RVO in the Sardinian
populatio
ciency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against
ischemic heart and cerebrovascular disease. The purpose of
this study was to assess the frequency of G6PD deficiency in
Sardinian patients with retinal vein occlusion (RVO) and to
ascertain whether the deficiency may offer protection against
RVO.
METHODS. Erythrocyte G6PD levels were measured in 448 consecutive RVO patients: 194 with central RVO (CRVO) and 254
with branch RVO (BRVO). Age- and sex-matched subjects (n
896) who were undergoing cataract surgery and had no history
of RVO served as the control. Multiple logistic regression models were used to investigate the association between G6PD
deficiency and RVO, CRVO, or BRVO.
RESULTS. G6PD deficiency was found in 21 (4.7%) patients with
RVO, 7 (3.6%) with CRVO, 14 (5.5%) with BRVO, and 107
(11.9%) control subjects. Differences between cases and controls were statistically significant (P 0.005). Multiple conditional logistic regression analysis, including as covariates G6PD
deficiency, hypertension, diabetes, and hypercholesterolemia,
revealed that G6PD deficiency was significantly associated with
decreased risk of development of RVO, CRVO, or BRVO. After
adjustment for hypertension, diabetes, and hypercholesterolemia, the association between G6PD deficiency and RVO,
CRVO, or BRVO remained statistically significant. Similar results were obtained after adjustment for systolic or diastolic
blood pressure, plasma glucose, and cholesterol levels. However, when the patients with CRVO or BRVO were categorized
by gender, a significant association was found only in the
women.
CONCLUSIONS. The frequency of G6PD deficiency in patients
with RVO was significantly lower than expected. The results
suggest that G6PD-deficient patients have a significantly decreased risk of development of RVO in the Sardinian
populatio
Iris type:
1.1 Articolo in rivista
List of contributors:
Pinna, Antonio; Carru, Ciriaco; Solinas, Maria Giuliana; Zinellu, A; Carta, F.
Published in: