Osmium(II) CNN Pincer Complexes as Efficient Catalysts for both Asymmetric Transfer and H2 Hydrogenation of Ketones
Academic Article
Publication Date:
2008
Short description:
Osmium(II) CNN Pincer Complexes as Efficient Catalysts for both Asymmetric Transfer and H2 Hydrogenation of Ketones / W., B., M., B., Chelucci, G.A., K., S., P., R.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 47:(2008), pp. 4362-4365. [10.1002/anie.200800339]
abstract:
we have described the isolation of the first
CNN pincer osmium complexes [OsX(CNN)P2] to display
high catalytic activity and productivity in the reduction of
ketones by either TH or HY (TOFand TON up to 106 h1 and
105, respectively). A high enantioselectivity (up to 98% ee) is
possible in both reactions with a remarkably low catalyst
loading (0.005–0.002 mol%). To the best of our knowledge,
this is the first example of an osmium complex that catalyzes
the asymmetric HY of ketones. Evidence for an Os-OR vs.
Os-H equilibrium suggests that both these species are
involved in the catalytic pathways.
CNN pincer osmium complexes [OsX(CNN)P2] to display
high catalytic activity and productivity in the reduction of
ketones by either TH or HY (TOFand TON up to 106 h1 and
105, respectively). A high enantioselectivity (up to 98% ee) is
possible in both reactions with a remarkably low catalyst
loading (0.005–0.002 mol%). To the best of our knowledge,
this is the first example of an osmium complex that catalyzes
the asymmetric HY of ketones. Evidence for an Os-OR vs.
Os-H equilibrium suggests that both these species are
involved in the catalytic pathways.
Iris type:
1.1 Articolo in rivista
Keywords:
asymmetric catalysis · hydrides · hydrogen transfer · hydrogenation · osmium
List of contributors:
W., Baratta; M., Ballico; Chelucci, Giorgio Adolfo; K., Siega; P., Rigo
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