Carboplatin Sustained Delivery System Using Injectable Microspheres

A controlled carboplatin delivery system using biodegradable
polymer has been used in this study. The purpose was to
evaluate the local and systemic effects of injectable, biodegradable
microspheres containing carboplatin when injected as
aqueous suspension subcutaneously in rats. Biocompatibility
and toxicity of empty microspheres and microspheres loaded
with carboplatin were evaluated by clinical and histological
examination. The diffusion of carboplatin in tissues and time
of drug release were evaluated by platinum determination in
plasma and tissues over the time. The results of the study
suggest that microspheres provide a sustained slow release of
carboplatin and that multiple inoculations of microspheres
containing drug and no evidence of local or systemic toxicity is
found. This device may be useful in the treatment of solid
tumours.