Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation
Academic Article
Publication Date:
2010
Short description:
Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation / Rizza, S., Cardellini, M., Martelli, E., Porzio, O., Pecchioli, C., Nicolucci, A., Marx, N., Lauro, D., Ippoliti, A., Romeo, F., Lauro, R., Federici, M.. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 212(1):(2010), pp. 316-320.
abstract:
Objective: The roleofinflammatoryadipokineshasclearmechanisticeffectsinthepromotionofbothDM2
and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma-
tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis
that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes
mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof
atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease
(CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD).
Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle-
rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest
the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand
diabetes weusedlogisticandregressionanalysismodels.
Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel
districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors
we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease
extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation
status (p = 0.012and p < 0.001,respectively).
Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose
regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.
and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma-
tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis
that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes
mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof
atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease
(CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD).
Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle-
rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest
the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand
diabetes weusedlogisticandregressionanalysismodels.
Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel
districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors
we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease
extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation
status (p = 0.012and p < 0.001,respectively).
Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose
regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.
Iris type:
1.1 Articolo in rivista
List of contributors:
Rizza, S; Cardellini, M; Martelli, Eugenio; Porzio, O; Pecchioli, C; Nicolucci, A; Marx, N; Lauro, D; Ippoliti, A; Romeo, F; Lauro, R; Federici, M.
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