Publication Date:
2006
Short description:
Human chitotriosidase helpsPlasmodium falciparumin theAnophelesmidgut / Di Luca, Marco; Romi, Roberto; Severini, Francesco; Toma, Lucio; Musumeci, Marco; Fausto, Anna Maria; Mazzini, Massimo; Gambellini, Gabriella; Musumeci, Salvatore. - In: JOURNAL OF VECTOR BORNE DISEASES. - ISSN 0972-9062. - 43:3(2006), pp. 144-146.
abstract:
High levels of plasma chitotriosidase (Chit) represents
a marker of macrophage activation in human
malaria infection.Plasmodium falciparumduring
its maturation cycle in theAnophelesmidgut produces
an analogue of Chit for the digestion of
peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could helpP. falciparumto complete its cycle in theAnophelesmidgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous
Hb beta (S) gene, which seems to be associated with
an increasing effect onP. falciparumtransmission from humans to mosquitoes.
a marker of macrophage activation in human
malaria infection.Plasmodium falciparumduring
its maturation cycle in theAnophelesmidgut produces
an analogue of Chit for the digestion of
peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could helpP. falciparumto complete its cycle in theAnophelesmidgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous
Hb beta (S) gene, which seems to be associated with
an increasing effect onP. falciparumtransmission from humans to mosquitoes.
Iris type:
1.1 Articolo in rivista
Keywords:
Chitotriosidase; peritrophic matrix; malaria;Plasmodium falciparum
List of contributors:
Di Luca, Marco; Romi, Roberto; Severini, Francesco; Toma, Lucio; Musumeci, Marco; Fausto, Anna Maria; Mazzini, Massimo; Gambellini, Gabriella; Musumeci, Salvatore
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