Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest
Academic Article
Publication Date:
2004
Short description:
Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest / Sechi, Mario; Sannia, Luciano; Orecchioni, Maria; Mura, Alessio; Paglietti, Giuseppe. - 2004:Part 5(2004), pp. 97-106.
abstract:
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, a
new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an
intramolecular Friedel-Crafts acylation, as a synthon suitable to be functionalized to give novel
compounds with potential biological properties. Also, an unusual nucleophilic α-addition to
methyl propiolate by 1,5,6,7-tetrahydro-4H-indol-4-one was observed and discussed.
new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an
intramolecular Friedel-Crafts acylation, as a synthon suitable to be functionalized to give novel
compounds with potential biological properties. Also, an unusual nucleophilic α-addition to
methyl propiolate by 1,5,6,7-tetrahydro-4H-indol-4-one was observed and discussed.
Iris type:
1.1 Articolo in rivista
Keywords:
Tetrahydropyrrolo-[1,2-a]indole-1,8-dione; intramolecular Friedel-Crafts; Michaeltype α-addition
List of contributors: